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The pathway and functional analyses were conducted using the Ingenuity Pathway Analysis IPAA) software (Ingenuity Systems, Redwood City, CA, USA).
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All modeling and ordination analyses were conducted using R R Development Core Teamm, 2009).
Univariate and multivariate analyses were conducted using RStudio.
Preprocessing and whole-brain analyses were conducted using the AFNI (Analysis of Functional Neural Images) software (Cox, 1996).
Gene ontology analyses were conducted using DAVID Bioinformatics Database functional-annotation tools, as we have previously described.
Bioinformatics analyses were conducted using the MAS3.0 system (CapitalBio, Beijing, China) and DAVID Functional Annotation Bioinformatics Microarray Analysis (http://david.abcc.ncifcrf.gov).abcc.ncifcrf.gov
Analyses were conducted using StatsDirect and STATA.
Descriptive analyses were conducted using percentages, means, and standard deviations.
Sensitivity analyses were conducted using alternative efficacy and tolerability data.
Statistical analyses were conducted using Analyse-it® and Microsoft Excel®.
Analyses were conducted using SAS version 9.3.
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