Sentence examples for and function of targeted from inspiring English sources

Taken together, this strategy has two advantages: (1) inserted exogenous genes can faithfully recapitulate the expression pattern of targeted endogenous genes; (2) the expression and function of targeted endogenous genes are maintained.

In addition to its ability to directly alter the structure and function of targeted proteins within cells that causes cell or tissue damage, emerging evidence has also demonstrated AGEs as a signaling ligand, interacting with RAGE; AGEs elicit signal transduction changes that adversely affect numerous peripheral organs.

Thus, the recombinant bacterial surface display system may not be suitable if glycosylation is vital for the folding and function of target proteins [ 29].

We hypothesize that CDR internalization affects activity-dependent modifications of synaptic integrity, stability, and function of target proteins, which modulates the synaptic Ca2+ transient by mediating over-activation of calpain-2 [ 5, 17].

These reactions, together with intra- and intermolecular cross-link formation, are able to modify structure and function of target molecules in such a way that they do not respond anymore to biological signals [ 40, 41].

Many studies have investigated presence, levels and function of antibodies targeting VSA-PAM, but less is known concerning the dynamics of binding interactions.

Beyond control of protein translation: what we have learned about the non-canonical regulation and function of mammalian target of rapamycin (mTOR).

The choice of detergent to solubilize a membrane protein from its lipid membrane may be tricky, since it affects the structure, stabilization, and function of the target protein.

As an upstream regulator of TGF-β signaling, miR-155 decreased the expression and function of SMAD2 by targeting the SMAD2-3′UTR.

Heat shock protein (HSP90) is a chaperone protein that helps maintain structural integrity and function of specific protein targets involved in cell cycle.

Due to these pharmacological properties, conopeptides can be ideal tools to study the structure and function of a given target (see below).