Sentence examples for and function of numerous from inspiring English sources

Zinc is one of these ions which has a fundamental role in the structure and function of numerous proteins, including metalloenzymes, transcription factors, and hormone receptors.

Helix helix interactions, such as those that occur in coiled-coil domains, four-helix bundles, or membrane-spanning helical bundles, are important to the structural organization and function of numerous proteins.

In fact, while NO itself is fairly non-toxic and protective, the secondary reactive nitrogen species generated in the presence of free oxygen radicals are potent oxidant and nitrating agents that can modify the structure and function of numerous biomolecules both in vitro, and in vivo[25], [10].

Bone morphogenetic protein (BMP) signaling is crucial for the development and function of numerous organs, but its role on the function of pancreatic islets is not completely clear.

This is significant given that RACK1 affects the subcellular distribution and function of numerous proteins and, as a result, plays an essential role in regulating signaling pathways in many key biological processes [ 46, 47].

For instance, abnormal expression, regulation and function of numerous GPCRs have been associated with cancer initiation, progression, invasion and metastasis (Lappano and Maggiolini, 2011, 2012; O'Hayre et al., 2014).

Such information may be of high value for our understanding of C. elegans biology: the exact and true function of numerous genes, many of which are still of unknown function, may only be revealed if the species' natural conditions are taken into account.

Although Cu(2+) is an essential element for life and the function of numerous enzymes is basic to neurobiology, free or incorrectly bound Cu(2+) can also catalyze generation of the most damaging radicals, such as hydroxyl radical, giving a chemical modification of the protein, alternations in protein structure and solubility, and oxidative damage to surrounding tissue.

By mimicking the size and function of viral vectors, numerous nonviral gene delivery systems based on biocompatible nanostructured materials, such as inorganic nanoparticles, carbon nanotubes, liposomes, cationic polymers, polypeptides, and dendrimers, have been developed to provide an alternative approach to the problems encountered in viral gene delivery.

This would compromise gene regulation and hence the function of numerous downstream genes and vital biological processes, including the development of transmission stages.

Therefore, any coding mutations in mitochondrial DNA will affect the entire electron transfer chain, potentially altering both the assembly and function of the products of numerous nuclear genes in electron transfer chain complexes.