Evaluation of genes reported to be dysregulated in miR-208a mutant mice revealed elevated levels of Egr1, Egr2, and Fos in the heart, suggesting a potential relationship between miR-499 and miR-208 in regulation of the immediate early gene response to cardiac stress.
The protein interactions and expression of Jun and Fos in the network for HF are similar to those in LF (Additional file 1, Figure S8), indicating that these interactions via AP-1 remain unaffected by obesity and insulin resistance.
The mean age of those patients was 62 years (ranging from 16 to 90 years), and we obtained frontal radiographs of the hips (including the pelvises) for the assessment of HRC and FO in the standing position as previously performed in the similar studies [ 14– 16, 22].
PRF application at DRG may alter the biological actions on synaptic transmission, cell morphology, and Fos expression in the superficial dorsal horn of the spinal cord, with trivial effects on nerve tissues [ 18– 20].
PV and FO participated in the design of the study and the drafting the manuscript.
The perineural administration of BV to the spinal nerves attenuated the development of mechanical, thermal, and cold allodynia, and the BV pretreatment reduced the expression of TRPV1, TRPA1, TRPM8 and c − Fos in the ipsilateral dorsal root ganglion.
Since loss of AP1 activity could be a direct result of loss of expression of AP1 family protein that forms functional homo/hetero-dimer of active AP1 complex, we checked the effect of B. pinnata crude leaf extract and fraction F4 on expression of AP1 family proteins, c-Jun, JunB, JunD and c- fos in the treated cells by immunoblotting.
EG, JO, JJ, and FO participated in the design of the study and assisted writing of the manuscript.
HY and FO participated in the design of the study, acquisition, analysis and interpretation of data, and was involved in drafting the manuscript.
In situ hybridization using the primary visual cortex (V1, Figure S6A) showed that the expression of the immediate early genes Arc and c-fos in the monocular regions of V1 was markedly suppressed by TTX treatment (Figure S6B, C), as reported previously [45], [46].
In general, PHB1 co-localized with p53, Rb, E2F, AIF, c-myc, and c-fos in the nucleus [ 25, 27, 42– 42].
