We show here that collaborative responses mediated by Dectin-1 and TLR2 are more extensive than first appreciated, and result in enhanced IL-23, IL-6 and IL-10 production in DC, while down-regulating IL-12 relative to the levels produced by TLR ligation alone.
Interleukin-7 (IL-7) is required for T cell development and survival (reviewed in Khaled and Durum [1]) as first appreciated from the severe lymphopenia observed in IL7−/− and IL-7R−/− mice [2], [3], then in comparable deficiencies in humans found to lack components of the IL-7 receptor [4] (reviewed in Puel and Leonard [5]).
The association of military blast exposure and brain injury was first appreciated in World War I as commotio cerebri, and later as shell shock.
This suspension was easily extracted through use of closed syringes, and provided adipose tissues with reduced damage and improved grafting results. 1 In the mid-1980s, the importance of tumescent fluid distribution was first appreciated, and more value was placed on extensive pre-tunneling (moving cannula without applying vacuum).
Since the effects of botulinum toxin type A on glabellar lines were first appreciated, safety and efficacy have been supported and documented by numerous studies as well as extensive clinical experience.
FoxM1 is important to beta cell replication, and its role in tissue regeneration was first appreciated using partially hepatectomized mice.
Purists may pooh-pooh drinking it, but did you know that this is how chocolate was first appreciated by the Aztecs and the Europeans many centuries ago?
Then it was back to Achiltibuie harbour, and the stretch of shingle beach where, all those years ago, I first appreciated the beauty of the Summer Isles.
'I thought, my life has changed gear' He was 15 when he first appreciated what being an actor might mean.
It was the moment, Norman suggests, when the public first appreciated that crucial possibility: that there might be an alternative.
