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This molecule increased after JNK2 silencing and failed to decrease after JNK2 pharmacological inhibition, thereby indicating that the increase in acidic vacuoles and lysosomes observed was due to their accumulation rather than a rise in their formation.
Xiang et al. (abstract 248) followed 60 women for up to 75 months after gestational diabetes mellitus and found a progressive fall in the acute insulin response to intravenous glucose, whereas insulin sensitivity was low at baseline and failed to decrease significantly during follow-up.
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In many studies, TPN was harmful or ineffective; specialized formulas for liver and renal disease, sepsis, and cancer failed to decrease morbidity, length of hospital stay, or mortality.
On the other hand, HCT116 p53−/− cells showed a continuous increase in cyclin B1 protein levels with time and finally failed to decrease the levels of cyclin B1 and pH3 at 48 h.
We employed cumulative meta-analysis to determine the typical estimate after each trial was added, and then performed multivariable logistic regression to determine factors predictive of study impact.For the stated primary outcome, 18% of latest RCTs failed to narrow the confidence interval (CI), and 55% failed to decrease the CI by ⩾20%.
The combination therapy beta-lactam and amikacin failed to decrease the emergence of resistance unlike in an in vitro study [20].
Unlike the reduction of microglial dendritic morphology seen with the application of NBQX alone, the concurrent application of both ATP and NBQX failed to decrease dendritic morphology.
Treatment with vigabatrin, sulthiame, and topiramate failed to decrease seizures, whereas implementation of steroid pulse therapy led to an improvement.
HDL-increasing drugs such as fenofibrate and niacin have failed to decrease the cardiovascular risk in patients with type 2 diabetes.
He states that "Contrary to our expectations, results showed that hearing "Pinocchio" and "The Boy Who Cried Wolf" failed to decrease children's tendency to lie about their own transgression.
170, 172 Consistently, leptin injections failed to decrease body weight and hyperglycemia adequately in middle-aged obese and diabetic subjects.
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