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Other interesting findings include the variation in the timing and extent of expression during development.
cxcr4b is expressed in dHb neuronal precursors around the time at which they generate postmitotic neurons [ 23], and the timing, asymmetry, and extent of expression are not affected in 32 hpf (hours postfertilization) mutants.
Based on these earlier findings and their ability to promote fracture healing and bone fusion, we studied the above-mentioned osteoinductive BMPs for their eventual presence, cellular localization, and extent of expression in the peri-implant synovial membrane-like interface tissue around aseptically loosened THRs, in control synovial membranes and in MSCs and osteoblasts produced from MSCs.
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The current study suggests that patterns and extents of expression of Dnr-transcripts, expressed in cells resident to the wound and proximal skin, as well as specific Upr-transcripts, may contribute to the prediction or identification of poorly healing wounds, and may be useful for indicating wound-specific treatments to improve wound outcome.
Having demonstrated a direct correlation between the level of UBP43 mRNA induction and extent of ISG expression, we next tested whether exogenous expression of UBP43 could suppress IFN-α-induced phosphorylation of STAT1 in BL cells (A.2) in which phosphorylation is otherwise sustained.
To investigate this idea, we have set out to establish whether breast cancer cells maintain or upregulate PTHRP-R expression in these lesions by comparing the frequency and extent of PTHRP-R expressinn in BM with that in primary breast cancers.
A previous study in colorectal cancer reported the predominant expression of miR-21 in CAFs and showed that the frequency and extent of its expression increase during colorectal cancer progression from precancerous adenoma to advanced carcinoma [ 45].
Increased intensity and extent of MMP-2 expression was shown by rapidly thawed specimens.
In contrast, overexpression of bmp2b or knockdown of matriptase-2 enhanced the intensity and extent of hepcidin expression in zebrafish embryos, but this occurred in an hjv-independent manner.
We examined the in vivo significance of these interactions in the inner ear, where Lrig3 controls semicircular canal formation by determining the timing and extent of Netrin1 expression in the otic vesicle epithelium.
In comparison to uninjected WT embryos at 55 hpf (Figure 3A), induction of bmp2b by heat shock at 48 hpf in tg(hsp70 bmp2b) resulted in increased intensity and extent of hepcidin expression in the liver and foregut (Figure 3B) by whole mount in situ hybridization, while treatment with dorsomorphin from 28 55 hpf (Figure 3C) abrogated hepcidin expression.
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