The phrase "and extensive accumulation of" is correct and usable in written English.
It can be used when discussing a large collection or gathering of something, often in a formal or academic context.
Example: "The research revealed an extensive accumulation of data over the past decade, highlighting significant trends in climate change."
Alternatives: "and significant collection of" or "and large gathering of".
Unusual for PD, however, was the severe neuronal loss in the CA2/3 subregions of the hippocampus and the extensive accumulation of neuronal α-synuclein in the hippocampus, including the DF, and striatum [ 7, 8, 38, 52].
It was initiated by sudden instability after the Deccan volcanism and resultant extensive accumulation of lava pile over continental lithosphere of northern India, northern-eastern tilt due to crustal thickness heterogeneity and subcrustal thermal stratification.
Downregulation of COG3 resulted in the formation of Golgi mini-stacks and an extensive accumulation of small vesicles distinct from COPI-coated vesicles (38), whereas knockdown of COG5 in CHO cells showed dilated Golgi cisternae (45).
Importantly, simultaneous knockdown of faf and dor causes more extensive accumulation of Fmi in intracellular vesicles than knockdown of dor alone (Fig. 5L,M), consistent with a failure of Fmi deubiquitylation normally promoting lysosomal degradation of Fmi.
By 3 months of age Tau4RTg2652 mice exhibit motor and learning deficits accompanied by extensive accumulation of soluble human tau and measurable detergent insoluble aggregated tau species.
Durability, unsustainable use, and inappropriate waste management cause an extensive accumulation of plastics in natural habitats [[2]].
However, in cases of MND and normal controls, we found less extensive accumulation of HSP27 immunoreactive granules in these same brain areas.
Obesity, aging, and other conditions are associated with extensive accumulation of senescent cells in fat tissue of rodents as well as humans, in whom fat is frequently the most abundant tissue in the body [ 2- 4].
(http://www.facs.org/cancer/ncdb/index.html) The NCDB has never reported the collected data on soft tissue sarcomas, despite the extensive accumulation of demographic and survivorship data on such sarcomas.
