Indeed, a role for enzalutamide in all patients with metastatic CRPC is hinted at by the data from the Phase I/II studies, where enzalutamide appeared efficacious (and potentially even more efficacious) in chemotherapy-naïve patients.
Thus, further inclusion of a Bcl-2 or Mcl-1 inhibitor to this regimen may result in even more efficacious anticancer efficacy than the combination of LBH589 and TRAIL and should be further explored.
Additionally, the level of Yap expression/activation in adult cardiac progenitor cells is not known and it would be interesting to determine whether Yap could serve as a marker of cardiac progenitors, similar to c-kit, Islet-1, Sca-1 etc., that proves even more efficacious and overcomes the limitations of those populations being isolated and used currently [147].
It is also imperative to examine how these vulnerability factors interrelate in order to more fully understand the mechanisms leading to depression, and thus identify the most appropriate points for intervention and guide the development of even more efficacious treatments of depression.
18 compounds were found to increase β-galactosidase activity at 10 µM and two compounds (Cpd4 and 5 in Figure S3) were even more efficacious than Cpd1.
However, regulators should be encouraged to also use more effectively the other tools in their toolboxes, many of which may be even more efficacious than capital, and when added to sound capital rules make for a truly sound regulatory platform.
The introduction of anthracyclines and, recently, taxanes has significantly improved the efficacy of adjuvant chemotherapy and has provided useful insight regarding future development of even more efficacious regimens.
KD025 appeared even more efficacious in females (42% reduction in infarct volume).
Given that the treatments applied in this study alone are recommended and, for most of them, well documented in the treatment of KOA [ 5, 6], we contend that the combination of treatments would be even more efficacious.
Although the Picard review identified a primary reference treatment, researchers may have wanted to test yet another experimental intervention that may have been even more efficacious, or simpler to use.
