If applied to the full alignment of 427 sequences, the optimal clustering parameters resulted in 117 clusters (taxonomic units or TU) and 199 distinct combinations of TU and GenBank "organism" entry.
For instance, genotypic resistance to the protease inhibitor ritonavir arose at widely different times and through distinct combinations of mutations in different patients [3].
Orthologous monocot and dicot promoters have distinct TFBS classes involved in disease and oxidative-regulated expression, while the orthologous rice and sorghum promoters have distinct combinations of root-specific signals, a pattern that is not particularly conserved in Arabidopsis.
The platypus TERT clones were RT-PCR amplified from cDNA obtained from platypus brain testes, ovary, heart, and muscle using 15 distinct combinations of primers Table S1c, Additional file 1).
By assessing the magnitude of activation of UPR sensors and target genes in the liver of zebrafish larvae exposed to three commonly used ER stressors (tunicamycin, thapsigargin and Brefeldin A), we have identified distinct combinations of UPR sensors and targets (i.e. subclasses) activated by each stressor.
These analyses reveal novel PTMs on histones and protamines, and are the first to show distinct combinations of protamine PTMs, reminiscent of the histone code.
Distinct combinations of SaPI and plasmids or plasmids and genes of egc operon enterotoxins were found in the CNS strains obtained from salami.
It is possible that the specification of root expression in rice and sorghum are facilitated by distinct combinations of root-specific regulatory signals, with the rice orthologs making use of TALE/Homeodomain, TCPF, HOCT and CDC5/MYB elements, and sorghum orthologs making use of BRRE, E2FF/E2F-DP, SBPD and ROOT elements.
Individual fusion reactions are executed by distinct combinations of SNARE and SM proteins to ensure specificity, and are controlled by regulators that embed the SM-SNARE fusion machinery into a physiological context.
Consequently, the development and progression of knee OA can result from multiple, distinct combinations of numerous musculoskeletal and neuromuscular traits.
