For these reasons, we have here interpolated between the results obtained from a sensitivity analysis of the original model, and the outcome from a previous model simplification [ 15], with the rational being that such an analysis may be instructive for assessing what we can and cannot discover using a sensitivity analysis.
SNP and indel polymorphisms between the WY96 and Schu S4 genomes were discovered using a Perl pipeline called SIDACS (a SNP and Indel Discovery And Classification System based on MUMmer and developed jointly between TGen and NAU) [39].
Recent studies have confirmed ~40 genetic loci associated with type 2 diabetes (5); most of these loci were discovered in genome-wide association studies (6– 16), with the exception of PPARG (17), KCNJ11 (18), and WFS1 (19), which were identified using candidate gene approaches, and TCF7L2, which was discovered using a linkage-positional cloning strategy (20).
The results from the DoE analyses also revealed the lack of linearity of effects for certain responses with a significant curvature in the model which would otherwise not be discovered using a trial-and-error approach.
Interestingly, the method was discovered using a computer algorithm which automatically designs new quantum experiments66.
The neuron in question was discovered using a new brain mapping technique.
Recently, cis-acting regulatory SNPs have been discovered using a regional association approach [10], [11].
The other ABA transporter was discovered using a different approach.
One such molecule, LJ001, was discovered using a pseudotyped VSV virus with a luciferase reporter [ 84].
A new set of rules has been discovered using an evolutionary technique called cellular programming.
Small-molecule inhibitors of Nek2 were discovered using an in-house library of compounds.
