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The main consequences of use and abuse of antibiotics is the development and diffusion of antibiotic resistance that has become a serious global problem.
The main consequences of use and abuse of antibiotics is the development and diffusion of antibiotic resistance that represent a public health problem, with obvious consequences in human and veterinary medicine, since it affects animal therapy and food safety [ 5, 6].
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Among HGT mechanisms, those specified by conjugative plasmids seem to be the most sophisticated and implicated in the diffusion of antibiotic resistance genes [1].
Selective pressure by indiscriminate use of antibiotics and mechanisms of horizontal gene transfer have undoubtedly contributed to the emergence and diffusion of multi- resistance in Shigella [ 6].
This strong and continuously remodeled physical barrier blocks the diffusion of antibiotics, superoxides, immunoglobulins, and opsonins [ 21, 25].
But the origin and diffusion of religion, like the origin and diffusion of music, laughter, and xenophobia, reside in a largely irretrievable evolutionary past.
Further health improvements were achieved between 1951 and 1976, probably thanks to the diffusion of antibiotics.
Intracystic infections may moreover be different as the diffusion of antibiotics may be altered and the inflammation may persist longer.
15– 19, 19– 21 We model release kinetics by describing diffusion of antibiotics through a spherical carrier and degradation of the carrier system itself, with time varying boundary conditions.
However, due to autoradiography poor spatial resolution, the diffusion of antibiotics within the vegetation bacterial masses has not been studied.
The diffusion of antibiotics in the endocarditis vegetation bacterial masses has not been previously reported, although poor diffusion is a potential risk factor for antibiotic therapy failure.
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