Sentence examples for and difficult to target from inspiring English sources

Vital assets are well protected and difficult to target.

Lentiviral vectors (LVs) are promising tools in gene therapy for hematological diseases because they can efficiently transduce HPCs, which are quiescent and difficult to target [ 3].

Similar concerns were raised 20 years ago about protein kinases "serving critical cellular functions" and "difficult to target specifically", when the first-generation tyrosine kinase inhibitor "Gleevec" was discovered and fast-tracked to market 10 years later [ 80].

Most patients are struggling with breathing problems by the time they are diagnosed, and most of these cancers are already stage IV they have spread extensively to cervical lymph nodes and distant organs such as lung and bone, and are difficult to target and kill even with surgery.

As for most protein protein interaction interfaces, the NEMO IKKβ interface is extended and prevalently flat and possibly difficult to target with small molecule inhibitors, but rational inhibitor design would greatly benefit from the knowledge of the structure of unliganded NEMO or NEMO in the presence of small molecule ligands.

IS military tactics of sowing confusion coupled with speed, fearless resolve, and the use of land mines and buried explosives, has made it a formidable opponent on the ground and more difficult to target from the air.

It wasn't true, yet I found the idea analogous to the problem of developing good clinical education: it's difficult to see and thus difficult to target for rewards.

Several of these genes are also tumour suppressors and therefore difficult to target [ 51, 52].

Taken together, these data have led to a general belief that innate immune responses are crucial to the manifestations of RA, and that adaptive immune responses may be less important in the pathogenesis of the disease and more difficult to target.

173 In general, HTS is less successful in identifying PPI inhibitors than in identifying any other type of inhibitor: PPI are extended over a big interface (average binding energy per unit area: 9 cal/mol·Å) 154 and are difficult to target with a small site-specific drug (average binding energy per unit area: 31 cal/mol·Å).

Artisanal gold miners are typically the poorest and most marginalized in society [5], [8], [9], and therefore are difficult to target and regulate with education and incentives.