Sentence examples for and difficult to elucidate from inspiring English sources

However, only a fraction of the GPCRs have experimental structures (Venkatakrishnan et al. 2013), because the structural resolution of membrane proteins like GPCRs is much more complicated and difficult to elucidate than global proteins such as enzymes.

However, the dynamics of dissemination and ecology of acquired antibiotic resistance (mediated by resistance determinants that are not present normally in bacteria) are very complex [2] and difficult to elucidate.

For common variants, the biological effects are often weak and difficult to elucidate, and the correlation between expression levels of TGR5 and rs11554825 genotypes was not strong, but still in line with recent findings in other diseases [49], and could therefore be speculated to contribute to the associations with PSC and UC.

However, the pathogenesis of DDDs is complicated and difficult to elucidate.

Cross-feeding is an obvious example of a microbial interaction, but some described or implied interactions are more complex and difficult to elucidate.

The responses of plant fungal interactions to increased atmospheric CO2 concentration may be more complex and difficult to elucidate than the observed changes in pollen production and allergenicity.

The relative abundance of soluble endogenous skelemin in our cell lines was very low, and therefore the interaction between endogenous skelemin and αIIbβ3 was difficult to elucidate and reproduce by coimmunoprecipitation and Western blot.

Reason for such divergent effect in men and women are difficult to elucidate, and could be related to the specific effect of different alcohol subtypes, or to the effect of the alcohol drinking pattern.

However, high resolution structural interaction mechanism between VGSCs and VTD is difficult to elucidate because of the large size and membrane localization of VGSCs.

There was no objective measurement of behaviour change in this trial cohort and it was difficult to elucidate exactly which components of the intervention were associated with the observed improvements.

The evolutionary relationships between the members of this large superfamily are complicated and have proved difficult to elucidate [ 19], but understanding of the superfamily in angiosperms (specifically Arabidopsis, rice, and Populus) has improved through the use of genomic history to complement phylogenetic analysis [ 18, 20].