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The Kaplan-Meier method was used to estimate time to progression, and differences were assessed using log-rank statistics.
Incidence of macroscopic necrosis was estimated by the Kaplan-Meier method, and differences were assessed by means of the log-rank test.
All experiments were repeated three times, and differences were assessed by the paired t-test.
Means (± SD) were used for continuous variables, and differences were assessed by unpaired t-tests.
The Kaplan-Meier method was used to estimate survival and differences were assessed by the log-rank test [ 16, 17].
Survival was analysed by Kaplan Meier survival curves and differences were assessed for statistical significance by log-rank test.
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The final maps were compared using the same strategy; the maps' accuracy and difference were assessed by comparing the SD predictions to observed data (RMQS and IGCS datasets) and to an available soil map (1 1M).
Mean values, the standard deviation (SD), and the coefficient of variation (CV% = SD/mean) were determined for all measures in men and women, and sex differences were assessed using a two-tailed, unpaired t-test.
An actuarial survival was performed using the Kaplan-Meier method, and the differences were assessed with logrank, Tarone-Ware and Peto-Peto tests.
Pooled mean Doppler measurements between the different regions did not show homoscedasticity and so differences were assessed using the Friedman test.
The durations of RFS and OS were analyzed by the Kaplan Meier method, and their differences were assessed using the log-rank test.
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