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The simulation results could be applied into the design and development of substrates for the immobilization of ribonuclease A.
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This library easily synthesized is of great interest for the identification and development of selective and specific substrates for still uncharacterized endoproteases.
Fertilization results in an initial loss of soil C followed by depletion of soil C substrates and development of a distinct and active fungal community.
Microbial community anticipated to be in use to support a growth and development of the plant in a substrate of low bioavailability and provide an acceptable growth and blossoming of T. patula under growth limiting conditions.
Nevertheless, after the culture expansion, a loss of cell adhesion in the substrate and development of multi-cell aggregates in the culture, resulting in cell death, was observed (Table 1).
The strategy used in the design of this fluorogenic substrate can be applied in future endeavors to development of substrates for caspase-3 inhibitor screening assays or for real-time detection of apoptosis in living cells.
A potential secondary substrate-binding pocket is frequently found in phosphatases, and this has implications for both substrate recognition and development of selective inhibitors.
Enriched biological processes related to up-regulated genes included RNA related processes, differentiation and development of epidermis and ectoderm, and cell-substrate junction assembly; whereas in the case of down-regulated genes the biological processes that were enriched included IGF-like growth factor signaling, somatic stem cell maintenance and apoptosis.
Gene ontology (GO) enrichment analysis revealed biological processes that were categorized into groups including RNA metabolic processes, differentiation and development of epidermis and ectoderm, and cell-substrate junction assembly (Table 1), findings that are in agreement with existing knowledge that pregnancy hormones promote the differentiation of mammary epithelial cells [ 3].
Here we describe the therapeutic potential of GSK-3 inhibitors and highlight our progress in the development of substrate competitive inhibitors.
An increased understanding of its composition and role in the maintenance of reentrant VT has led to the development of substrate modification approaches to ablation of unmappable VT.
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