Sentence examples for and development of significant from inspiring English sources

The response surface methodology was used for the identification and development of significant relationship between process variables.

No significant association could be found between marijuana use and development of significant fibrosis or cirrhosis measured with the APRI score.

We found a significant effect of AMM exposure on growth and development of glands; significant delays were seen at each of these time points except PND33 (Table 4; development in the PND33 control group was unusually poor compared with that of historical controls); these developmental delays were consistently detectable in whole mounts of the fourth and fifth inguinal glands.

Over the course of an 80-year career, Hedda was instrumental in the founding and development of three significant educational institutions.

To examine the relationship between microaneurysm (MA) turnover using automated analysis of fundus photographs (RetmarkerDR; Critical Health SA) and development of clinically significant macular edema (CSME) in nonproliferative diabetic retinopathy (NPDR).

Moreover, certain Salmonella strains have developed resistance even against newer agents like azithromycin and the development of significant resistance against the current generation antibacterial agents can be envisioned in near future [ 12, 13].

However, the clinical development of GSIs has been hampered by their low cytotoxicity against human T-ALL and the development of significant gastrointestinal toxicity derived from the inhibition of NOTCH signaling in the gut.

Transition from this socialist system to a market economy has been accompanied by a marked socioeconomic decline for many inhabitants, and the development of significant disparities.

Our results show that compared to thymocytes developing in DO11.10/Itk−/− mice, thymocytes in OT-II/Itk−/− mice receive reduced TCR signals, with reduced development of "naïve" transgenic CD4+ T cells, and subsequent development of significant numbers of peptide specific MHC class II restricted TCR transgenic CD8+ T cells.

Fukushima et al. (2005) examined the relationship between the inoculating dose of bacteria and the progression of osteomyelitis, and found that development of significant histological and radiographic signs of osteomyelitis required inocula of at least 6 × 10 CFU.

All 8 patients developed profound shock within the first 12 hours, requiring multiple colloid infusions plus inotropic support and with rapid development of significant fluid overload.