This hypothesis provides a framework for the design and evaluation of chemoprevention trials, including the rationale for the selection of agents that are likely to inhibit biological processes and the development of intermediate markers associated with carcinogenesis.
Recent studies suggest that the T-brain gene-2 (transcriptioniption factor is both necessary and sufficient for the development of intermediate progenitors in the developing cortex [16].
The spray drying technology is an attractive and promising alternative for the development of intermediate phytopharmaceutical products of E. dysenterica.
Early studies by Brown and Goldstein [ 6] demonstrated that oxidized LDL-C (ox-LDL-C) is a prerequisite for initiation of atherosclerotic lesions, leading to the development of intermediate and complex plaques [ 7, 8].
The distal "gap gene" in the leg disc is Distal-less (Dll) (Cohen and Jürgens 1989); dachshund (dac) is required for development of intermediate structures (Mardon et al. 1994); and proximal appendage development depends on the function of homothorax (hth) (Casares and Mann 2001).
A systematic review of longitudinal studies concluded that intravaginal cleansing with soap was associated with the development of intermediate vaginal flora and bacterial vaginosis in women with normal vaginal flora at baseline (pooled adjusted odds ratio 1.24, 95% CI 1.04 1.47) [ 55].
The unabsorbed factor induced not only cell aggregation (as shown in the form of simple apposition) but also cell adhesiveness characterized by development of intermediate junctions, desmosomes and tight junctions, while the absorbed factor produced only simple apposition, suggesting their functional difference.
A study of MSSA isolates has shown a reduction in autolysis and in the bactericidal activity of oxacillin after development of intermediate vancomycin susceptibility (2 ).
Formaldehyde is currently produced from methane by a three-step process involving H2/CO synthesis gas and methanol as intermediates, and development of a single-step process would have great economic incentive for producing this commodity chemical.
It results in the development of intermediate moisture products having lower water activity, which is imparted by solute gain and water loss.
