The phrase "and development of foot" is not correct and lacks clarity in written English.
It may be used in a context discussing the growth or improvement of foot-related aspects, but it requires additional context to be meaningful.
Example: "The research focuses on the anatomy and development of foot health in athletes."
Alternatives: "and growth of the foot" or "and enhancement of foot function".
As both DPN and PAD are associated with the development of foot ulcers and cardiovascular disease, clinicians should be aware of these high prevalences when dealing with patients with screen-detected diabetes.
Tenosynovitis or rupture of the tendon of the tibialis posterior is considered prevalent and important in the development of foot deformities in the feet of RA patients [ 2, 3].
If validation of the models is successful, the next step will be to run a clinical trial to test if the use of the model for the development of foot and ankle orthoses leads to improved efficacy.
In conclusion, increased PARP, reduced type 1 procollagen, and impaired skin structure are associated with the development of foot complications in diabetes and may constitute novel biomarkers to identify patients at maximal risk.
Longitudinal studies are needed to investigate the impact of inflammation on the development of foot ulcerations and their prognostic value.
Further studies should investigate whether an activation of the immune system precedes the development of foot ulcer and whether anti-inflammatory therapies might be effective.
Two key pathways have been postulated to contribute to the development of foot pain and deformity in IA: inflammatory and/or mechanical [ 59].
However, it remains elusive whether hyperglycemia itself has a direct influence on the development of foot ulcers and its complications, especially in ischemic conditions.
The advancement of 3D gait analysis has given a clearer insight into the complex interaction between the underlying mechanisms of inflammation and mechanical pathways that influence the development of foot problems in people with IA.
The improved peroneal motor NCV with ranirestat treatment suggests clinical benefit because an abnormal peroneal motor NCV has been associated with the development of foot ulcers and mortality (16, 17).
