Sentence examples for and develop rational therapeutic from inspiring English sources
Understanding the mechanistic consequences of cross-talking gene activities is essential if we are to unveil the molecular basis of oncogenic events and develop rational therapeutic interventions.
Thus, designing of dual inhibitor for these two targets seems rational and may provide effective therapeutic strategies against AD.
However, our findings indicate that the composition of HDL is altered in elderly subjects and may help to develop rational therapeutic strategies that aim to increase HDL functionality.
An ability to dissect this heterogeneity, to identify subgroups that represent common mechanisms of disease, will be critical to understanding the complexities of genetic alterations and to provide a framework to develop rational therapeutic strategies.
A GES list including most of relevant biological pathways in breast cancer will certainly help to gain more insight into biological systems involved in this disease and will provide a framework to develop rational therapeutic strategies based on meaningful subtyping.
However, we do not understand the pathobiology of many common ear disorders clearly enough to develop rational therapeutic solutions.
To develop rational therapeutic strategies, it is important to identify molecular targets that are linked to the pathogenesis of HNSCC.
This strategy, which can be strengthened by increasing the number of representative GES to gain more insight into biological systems involved in this disease, provides a framework to develop rational therapeutic strategies in function of age.
An ability to dissect this heterogeneity will facilitate a deeper understanding of the relevance of these alterations for disease phenotypes by which to develop rational therapeutic strategies that can be matched with the characteristics of the individual patient's tumor.
Identifying candidate NAFLD genes will be essential for enhancing our understanding of the genetic factors that are important in the pathogenesis and progression of NAFLD and in subsequently developing rational therapeutic strategies for this common liver disease.
Thus, the identification of specific markers defining breast cancer subtypes with particular sensitivity to ATRA and derivatives is likely to represent a priority in studies aimed at developing rational therapeutic approaches based on the use of these compounds.
