Sentence examples for and develop a potent from inspiring English sources

Here, we utilized the helix12 (H12 -folding inH12 -foldingothesinhibitionbination withypothesisinusly determined X-ray combinationucture of PPARγ agonist MEKT-21 (6) complexed with the PPARγ ligand-binding dourin, to design and developreviously phenylalkynyl amideterminedARγ antagonist 9i, focusing initially on pinpoint structural modification of the propanoic acid moiety of 6.

Further the predicted R326H and R356Q mutations can be further studied by wet lab scientist to investigate the evidence of Tyrp1 protein mutation in association to OCA3 and develop a potent drug target for OCA3.

In the current study, to elicit a more robust immune response and develop a potent vaccination strategy against trichinellosis, a heterologous prime-boost vaccination regimen for Ts87 was used in mice and the protective efficacy was evaluated compared to the homologous DNA prime-boost or protein prime-boost immunization alone.

We investigated the interrelationship between activation of protein kinase A (PKA) and protein kinase C (PKC) in the signalling mechanisms of TP and developed a potent pharmacological intervention based on this mechanism.

We have used structure-based drug design in conjunction with kinome profiling and cellular assays to develop a potent, selective, and irreversible BTK kinase inhibitor, QL47, which covalently modifies Cys481.

Several researchers attempted to identify mechanisms responsible for asphaltenes precipitation and deposition as well as to develop a potent and reliable representative model to quantitatively and qualitatively estimate the extent of asphaltene precipitation and deposition.

In this letter we describe how we modified substitution around this pharmacophore to develop a potent, selective and orally active renin inhibitor.

113 Their search was initiated by a high-throughput screen of their compound library followed by optimization of their lead structure to develop a potent, selective, and orally-available compound, (2E -3- 4- [2,4-bis trifluoromethyl benzyl] oxy)-3-methoxyphenyl)-2E -3- 4- [2,4-bis trifluoromethyl benzyladiazol-2E -3- 4- [2,4-bis trifluoromethyl benzyl

MDS' ultimate goal is to develop a potent cancer drug.

Further characterization of active compound will lead to develop a potent AD modulating agent.

Some people are working to develop a potent drug targets for skin (reduced pigmentation) disorders [ 84– 84].