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The salt bridge formed by the residues E345 and R350 was stabilized in the presence of glucose and destabilized in the presence of glucose-ATP (Figure S1A).
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As fluid flowing through the wavy plate, breaking and destabilizing in the thermal boundary layer are induced.
In contrast, RydC-S1/Hfq complexes appeared more susceptible to competition and were already destabilized in the presence of 10-fold excess of unlabelled RydC RNA (Author response image 1 panel B, lanes 8-14).
Whether there is indeed an interaction between Hsp90α and Hsp70-2, asuggesteded by the earlier observation of a Hsp90-Hsp70 complex in testis extracts [27], and whether Hsp70-2 is destabilized in the absence of Hsp90α, remains to be seen.
Interestingly, both the IL-6 and AEN transcripts, which are not destabilized in the presence of SOX, bear AU-rich elements in their 3'UTRs.
In contrast, insulin was destabilized in the presence of all the amino acids selected.
Deacylation tetrahedral intermediates of DD-peptidase catalysis are thought to be destabilized in the same way.
Interestingly, cotransfection of Brm and Hpo in S2 cells resulted in a lower Brm protein level, suggesting that Brm was destabilized in the presence of Hpo.
This interaction is destabilized in the presence of misfolded/unfolded proteins, resulting in the dissociation of GRP78/BiP from PERK, ATF6 and IRE1, thereby initiating the UPR.
It marks a major stride forward, at once sure-footed in its method and destabilizing in its effect.
Previously employed design strategies for bending vibration control of beams and isotropic plates are shown to be a subclass of general anisotropic plate control theory, and often destabilizing in the presence of anisotropy.
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