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Discover Ludwig"and despair" is a perfectly correct and usable part of a sentence in written English.
You can use it to express sadness, discouragement, or loss of hope. For example, "The news of their separation filled her with grief and despair."
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LOOK on and despair.
Murder, incarceration, drink, and despair.
Ahead lie anarchy and despair.
Massive destruction, displacement and despair.
Compare and despair.
But can you see joy and despair?
His photographs are about desire and despair.
"Living in Squalor, Decay and Despair".
Many more experienced exhaustion, rage and despair.
It is idleness, uncertainty and despair.
Faith and knowledge and hope and despair.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com