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"If we could simply take these poisonous drugs more directly to the tumors, it would increase their effectiveness and decrease side effects," Bhatia said.
These findings may provide useful information for designing drug delivery systems, which may improve anticancer efficacy and decrease side effects.
In 2014, Sepehri et al. determined the cytotoxic effect of HAS-SN38 nanoparticles on HT29 cells and showed that HAS-SN38 nanoparticles cause an increase in SN38 stability and decrease side effects due to the targeted treatment (Sepehri et al. 2014).
Overall, gliomas have a poor prognosis and developing novel modalities to increase antiglioma effects and decrease side effects is necessary.
To optimize the pharmacokinetics and decrease side effects, the development of protease inhibitor prodrugs could improve water solubility and bioavailability.
Since INT0116 trail [ 35], postoperative chemoradiotherapy became the trend of treatment for gastric cancer, and chemotherapy regimens had renewed constantly to enhance treatment efficacy and decrease side effects.
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The potency, selectivity, and decreased side effects of bioactive peptides have propelled these agents to the forefront of pharmacological research.
For some diagnostic agents including imaging or radio-labeled agents a shorter half life in circulation results in lower non-specific binding and decreased side effects.
This cancer-targeted design of SeNPs opens a new path for synergistic treating of cancer with higher efficacy and decreased side effects.
cRGD-SCM/DOX with a sustained release pattern exhibited prolonged circulation time, upregulated accumulation in tumor, enhanced tumor inhibition, and decreased side effects compared with free DOX and non-targeting SCM/DOX in vivo.
Finally, modern linear accelerators allow for modulation of the dose intensity of the radiation beam, which may lead to improved aesthetics and decreased side effects while ensuring that the volumes at high risk receive the prescribed dose.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com