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Docking the dataset (bioactives and decoys) into the protein target prepared with the same preparation scheme is a "matched" experiment, whereas, different preparation schemes for target and dataset will be called a "mismatched" experiment.

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Despite using this principle, it is still expected that a large number of factories and datasets will be defined and it can be difficult to keep track of which ones are available.

These methods and datasets will be introduced in an integrated way in subsequent sections, so that the research process can be more clearly expressed and understood.

Testing this framework in other populations and datasets will be important in order to investigate whether the dimensions of social vulnerability that emerge are consistent or different between studies and settings.

The protocol and clinical dataset will be made available upon request to any scientist wishing to use them for non-commercial purposes.

A HELP study website will be used to provide study updates (http://medicine.cf.ac.uk/help-study/), and a minimum dataset will be developed to collect follow-up data by telephone for those participants who are unwilling or unable to meet with the researcher.

In addition, demographic and past medical history data derived from the 45 and Up Study baseline dataset will be available for analysis.

The protocol and de-identified clinical dataset will be made available upon request to any scientist wishing to use them for non-commercial purposes.

Research questions and access to the whole dataset will be discussed within the TRI database scientific committee and has to be approved by it.

As the next-generation sequencing platforms are increasingly developing, gene expression datasets, such as the miRNA-perturbed gene expression (MPGE) datasets and the parallel miRNA/mRNA expression dataset, will be generated at an ever-increasing speed.

Unfortunately, in 2011 the ONS announced that the General Lifestyle Survey will be discontinued after January 2012, 23 so the 2010 and 2011 releases of the dataset will be the final opportunities for updating this analysis.

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