The phrase "and culminates in the activation of" is correct and usable in written English.
It can be used to describe a process or series of events that lead to a final outcome or result, specifically the activation of something.
Example: "The research process involves several stages, and culminates in the activation of the new software system."
Alternatives: "and leads to the activation of" or "and results in the activation of".
Nutrient depletion limits growth and proliferation and culminates in the activation of stress response genes.
This cascade is triggered by signals from cell-surface receptors and culminates in the activation of the mitogen-activated protein kinase (MAPK), an enzyme with hundreds of substrates, including transcription factors and regulators of cell shape, apoptosis and metabolism (Boulton et al., 1990; Futran et al., 2013).
Triggering of the apoptotic machinery in response to a variety of cellular stresses and physiological stimuli culminates in the activation of caspases, resulting in cell death.
This ultimately culminates in the activation of MMP-9 and mitochondria damage.
This pathway culminates in the activation of caspases 3 and 7, which are in turn inhibited by XIAP.
This leads to the release of Ptch-mediated repression of Smo and consequent activation of the downstream signalling cascade that culminates in the activation of the Gli family of transcription factors (Varjosalo & Taipale, 2008).
As ER stress culminates in the activation of the pro-apoptotic kinases JNK and p38 [34], we included phospho-JNK and phospho-p38 in our examination.
This interaction triggers a complex signaling pathway that culminates in the activation of interferon-β (IFN-β) gene expression.
Activation of the innate immune response initiates a conserved signaling cascade that culminates in the activation of transcription factors, such as nuclear factor kappa-B (NF-κB) [ 5].
Release of cytochrome c culminates in the activation of pro-caspase-9 within a multimeric cytosolic death inducing complex, the apoptosome.
This then culminates in the activation of effector caspases like caspase 3. To date, it is unclear what factors regulate the decision for the cells' fate.
