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Ras activates Raf-1 and contributes to the activation of PI3K (with FAK).
PIP3 is essential for the activation of Akt and contributes to the activation of Btk.
Phosphorylation of Tyr877 is mediated by Src and contributes to the activation of the ErbB2 tyrosine kinase, and Tyr1248 is an autophosphorylation site [ 24, 25].
Interferon appears to be an excellent adjuvant that enhances production of immunoglobulins and contributes to the activation of dendritic cells required for antigen presentation (21 – 21 ).
B4GALT is also identified as an apoptosis-related gene in some cancer cells and contributes to the activation of signal transduction pathways.
He demonstrated that the induction of mitochondrial superoxides results in mitochondrial membrane potential in primary hepatocytes and contributes to the activation of the col1a2 promoter in co-cultured hepatic stellate cells.
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These data indicate that NTG induces oxidative stress, which contributes to the activation of Nrf2/ARE pathway.
PKC activation contributes to the activation of MAPK, most probably via c-Raf-1 activation.
Subsequently, C5a contributes to the activation of the stress system.
In the brain, microglial activation contributes to the activation of another type of cell called astroglia, or astrocytes, which, like microglia, show multiple stages of neuroimmune activation.
These findings suggested that the existence of ER and PgR might contribute to the activation of MCN during pregnancy.
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