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The initial parameter set was applied and constrained in a secondary fit for each study subset to obtain an initial α estimate for each study.
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We reasoned that if selective pressures differed between the two groups, there should be sites undergoing substitutions in the AR-A subtree and constrained in the percomorph AR-B subtree, and symmetrically sites constrained in the AR-A subtree undergoing substitutions in the AR-B subtree.
The realization of such an alternative depends on many factors that are beyond this paper, which focused in particular on how open source models are only selectively enabled and constrained in their potential as an alternative in the life sciences.
However, Chavez has been cautious and constrained in his criticism.
He insisted beforehand that his previous undistinguished World Cup experience was no reason to change the managerial style that had delivered title after title at club level and Russia were constrained in a tactical straight-jacket.
After limiting the conserved quantities, the gradients of the velocity and energy density are constrained in a consistent manner.
Bacon recognised something fundamental about Velázquez, the claustrophobia of his portraits, and looking at Innocent X with his red face and red hat against a red curtain you too feel trapped, constrained in a hot and airless place... a hell.
In a photograph of Mohamed that has been circulating online, his wrists are constrained in a pair of handcuffs, and a police officer stands behind him.
As Theo, Byron Jennings, his hair plastered down, his body constrained in a snug three-piece suit, makes some delicious expostulations.
Several previous works have shown cis-regulatory motifs to be constrained in a position- and/or distance-specific manner [ 48, 49].
The design was within-subjects and stimulus presentation was constrained in such a way as to counterbalance the effect of target repetition across conditions.
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