The phrase "and constitute a substantial" is correct and usable in written English.
It can be used when discussing the significance or importance of something in a particular context, often in formal or academic writing.
Example: "The findings of this study and constitute a substantial contribution to our understanding of climate change."
Alternatives: "and represent a significant" or "and form a considerable".
These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment".
Glial cells slightly outnumber neurons in the human hippocampus and constitute a substantial volume fraction.
Also, mutations in TFBS underlie several degenerative human diseases (e.g., all forms of cancer) and constitute a substantial component of the phenotypic variability within and across species [ 5].
This secondary myelination is a result of maturation of endogenous oligodendrocyte precursor cells (OPCs), which persist throughout life and constitute a substantial proportion of cells in the CNS (∼4%; Keirstead & Blakemore, 1999; Keough & Yong, 2013; Staugaitis et al., 2012).
The Japanese population were repatriated back to Japan after the war, but most people of mixed Japanese Micronesian remained in the islands and constituted a substantial percentage in the islands' population.
This is remarkable and constitutes a substantial scientific gap, yet for bees in general, long-distance tracking methodologies have never been available.
Health care absorbs large private expenditures, sustained by households, remittances, charitable and solidarity funding, and constitutes a substantial portion of the country economy.
Consequently BD has significant impact emotionally and functionally [ 6] and constitutes a substantial financial burden to society: McCrone recently estimated cost to the English economy at £5.2 billion per annum [ 2].
NCT01228123, clinicaltrials.gov Acute renal failure (ARF) requiring intermittent or continuous renal replacement therapy (RRT) significantly affects morbidity and mortality of critically ill patients and constitutes a substantial health care burden [ 1].
In vertebrates, serpin genes are often arranged in tandem arrays and they constitute a substantial fraction of mammalian genomes.
