The deacetylated BubR1 can be ubiquitinated by the APC/C and consequently degraded, thereby releasing Cc20 to activate the APC/C against its metaphase substrates, cyclin B and securin.
They proposed that transcribed target SNPs alter miRNA gene regulation and, consequently, protein expression, thereby contributing to the likelihood of cancer susceptibility by a novel mechanism of subtle gene regulation [115].
In cochlear implant patients fibrous tissue will lead to increased electrode impedance and consequently increased power consumption, thereby reducing the efficacy of the device.
However when overexpressed, p21Cip1 forms an inhibitory complex with CYCLIN E/CDK2, leading to G1- and consequently S- phase arrest, thereby forming the G1/S checkpoint [46], [47].
Reducing inflammation and consequently inhibiting structural damage, thereby preserving patient function and quality of life, are the primary goals of rheumatoid arthritis (RA) therapy.
By contrast, the inactivated form of ACCα/β reduces the malonyl-CoA levels and consequently CPT1 is released, thereby promoting the β-oxidation of fatty acids in the mitochondria (Ha et al., 1994; Hardie and Pan, 2002; Lopez-Vinas et al., 2007).
This improved the OCT spot stability on the retina and consequently reduced the phase-noise, thereby enabling the detection of slower blood flows by extending the inter-B-scan time interval.
The results suggest that CAPC grafting induces bone remodeling, thereby enhancing osseointegration and consequently reducing postoperative waiting time after dental implant placement.
Such a decrease in the said overlap has a two-pronged role; primarily, it reduces the dot-impurity interaction and consequently the strength of dot confinement, thereby hindering and promoting the excitation at the same time [33].
Modern software systems are constantly increasing in complexity and supporting the rapid prototyping of such systems has become crucial to check the feasibility of extensions and optimizations, thereby reducing risks and, consequently, the cost of development.
