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Since a single miRNA is able to bind to and consequently regulate approximately up to 100 different transcripts, miRNAs truly represent master regulators of gene expression and influence virtually all cell activities and events, including cell proliferation, cell death, differentiation, metabolism, infection and cancer.
Among the positively selected genes, a Wiskott Aldrich syndrome protein and SCAR homologue (WASH) functions as a nucleation-promoting factor (NPF) to stimulate actin polymerization on endosomal membranes and consequently regulate vesicular trafficking25.
At first the system has been optimized in an atmospheric environment, based on the statistical analysis of the plasma records taken with a high speed camera to evaluate the induction effectiveness and consequently regulate and control the system settings.
The hydrophilic PEG chains control protein and peptide adsorption and consequently regulate the behavior of cells to the polymer surface.
MiR-19a and -19b may regulate PTEN dosage, and consequently regulate PGC proliferation.
This data suggests that, in at least certain cellular microenvironments, cell:cell interactions represent a novel way to activate STAT3 signaling, uncouple APC activation events and consequently regulate immunity and tolerance.
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Hence, we hypothesized that DTT could accelerate Fe3+ reduction, thereby modulating cellular iron traffic and, consequently, regulating the expression of the genes under study [reviewed in 20].
It is interesting to speculate that under pathological conditions, where extracellular ATP required for ecto-phosphorylation can reach high concentration [7], CD98 phosphorylation is especially effective, which affects cell-cell interactions and consequently regulates T cell-mediated immune responses.
HMGA1 can serve as a modulator of IGF1 (insulin-like growth factor 1) activity and consequently regulates glucose uptake [ 35].
Collectively, these data indicate that miR-126 regulates the expression of several components of the PI3K/AKT pathway and, consequently, regulates its activation by extrinsic stimuli such as SCF.
The PI3K-Akt pathway is proximal to endothelial nitric oxide synthase [ 9, 41, 42], and its activation also results in the phosphorylation of downstream GSK-3β and, consequently, regulating cell biological and pathological functions.
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