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Groove binding agents are known to disrupt the transcription factor DNA complex and consequently inhibit gene expression.
The vanadium borides generate prior to and consequently inhibit the formation of chromium borides during rapid solidification because of lower standard free energy of formation of the former.
Inhibiting MenB will prevent transfer of electrons in ETC and consequently inhibit the ATP production.
From the soil adsorption study, the values of K oc suggest greater adsorption in soil types and consequently inhibit the penetration of fungicide into water sources.
Besides offering increased donor states, the introduced defect states would also serve as recombination centers for electron hole pairs and consequently inhibit the charge collection.
Hence, we asked whether hypoxia could act as non-severe stress able to activate p53-target MDM2 and consequently inhibit HIPK2 and predispose to drug resistance.
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When applied to HIV pathogenesis, such a model of apoptosis resulting in NF-κB activation allows the prediction that inhibiting caspase 8, and consequently inhibiting apoptosis, might result in two independent beneficial outcomes for HIV-infected patients.
Together, we hypothesize that RILP interacts with RalGDS, and consequently inhibits its GEF activity, resulting in inhibition of RalA activation, thus suppresses the secretion and cytoskeleton reconstruction required for cell migration and invasion of cancer cells.
Addition of bafilomycin A1 to macrophages increases the pH of endocytic compartments by inhibition of the proton ATPase, and consequently inhibits LLO pore-forming activity (Beauregard et al., 1997; Shaughnessy et al., 2006).
Strikingly, cFLIP prevents the combination of Atg3 and LC3 by competitively binding Atg3 and consequently inhibiting autophagy152.
The authors' system detected dysfunctional patterns of bladder emptying and consequently inhibited the organ's sensory nerves and restored a normal pattern of urination frequency.
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