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Open image in new window Figure 6 G-Rh2 triggers the translocation of BAX and BAK, cytochrome c release, and consequently activation of caspase-9 in SW480 cells.
Cachexia leads to increased oxidative stress and consequently activation of protein degradation pathways in glycolytic myofibers.
The effect of FdUrd resembles that of hydroxyurea and its application probably causes stalled DNA replication and consequently activation of ATR-related protein.
It has been shown that removal of Pbs2 can lead to specific activation of Ste7 and consequently activation of Kss1 by hyperosmolarity stimulation (Fig. 1) [24], [25], [25].
TF1 cells show a constitutive activation of mTOR and, consequently, activation of protein synthesis/cell growth pathways.
The 26S proteasome is involved in the degradation of AUX/IAA proteins and consequently activation of auxin responsive genes [ 49].
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Nox4, indeed, is a constitutive active isoform [ 64] reported to be mainly present in nonraft region of the plasma membrane [ 39]. Figure 7 suggests that VEGF promotes the dissociation of both Nox2 and VEGFR-2 from Cav-1 and the consequently activation of Nox2 VEGFR-2 axis in nonraft fractions.
This inappropriate polarization of the cell body may alter the cytoskeletal organization of the cell and consequently activation.
As we have seen, DNA methylation in the oocyte is driven primarily by transcription events; consequently, activation of new transcription units or recruitment of new promoters would be predicted to create new hypermethylated domains, which could include new intragenic, methylated CpG islands.
It has been hypothesized that repetitive activation of trigeminovascular neurons and consequently repetitive activation of modulatory pain pathways may lead to impairment of function or partial neuronal cell damage in these areas through the liberation of free radicals [1].
This mechanism is a likely explanation why low-dose ciprofloxacin treatment of S. aureus resulted in an enhanced release of LTA and, consequently, to activation of PMN.
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