Sentence examples for and consequently activate from inspiring English sources

Growth factor stimulations significantly increase the dimer/tetramer PKM2 ratio in cancer cells and consequently activate the protein kinase activity of PKM2.

In addition to mediating receptor internalization, β-arrestins also serve as scaffold proteins, recruiting Src family tyrosine kinases to the phosphorylated GPCRs and consequently activate MAP kinases [21].

Once they are critically short, telomeres become dysfunctional and consequently activate a proliferative arrest called replicative senescence.

Thus, mild hypothermia may also up-regulate NMDARs and consequently activate the downstream pro-survival CREB signaling pathway.

For example, activation of acetyl-CoA synthetase 2 (AceCS2) by SIRT3 [ 44, 45] may elevate the AMP/ATP ratio and consequently activate AMPK.

In glioblastoma, NHERF1 loss from the PM has been shown to displace PTEN from the PM and consequently activate PI3K-Akt pathaway [ 14].

Therefore, while on the one side the HDAC inhibitor panobinostat functions at the histone level, acetylating and consequently activating the GADD45G promoter, on the other side the SIRT1 activator may function at the transcription factor level, deacetylating and consequently inhibiting the function of the GADD45G repressor.

Studies have shown that TLR3 pathway is critical in the pathogenesis of PBC [ 24- 26], and poly I C, a synthetic double-stranded RNA, can mimic the infection of retroviral RNA by interacting with TLR3 and consequently activating the innate immunity with series of cytokine production and activation of lymphocytes.

Of the 25 activation requests received for MiQuit within the study duration, only 11 (44%) successfully sent an activation text message which included the requested information and consequently activated MiQuit support.

The mechanism of action underlying this combination treatment likely modulates the immune suppressive tumor microenvironment and, consequently, activates cytotoxic CD8+ T cells capable of specifically recognizing and destroying tumor cells.

These findings reveal a direct role of HIF in regulating miRNA biogenesis and consequently activating the miR-215-KDM1B-mediated miR-215-KDM1B-mediated miR-215-KDM1B-mediated miR-215-KDM1B-mediated