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Our alternative hypothesis proposes environmentally (e.g., viral or toxin) induced initial autoimmune β-cell damage with progressively declining ability to meet the increased insulin demands of obesity-related insulin resistance and consequent presentation of clinical diabetes with less severe β-cell loss and fewer β-cell autoantibodies at onset (19, 20).
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Potential epidemiological limitations of studies on rare diseases as achalasia include inadequate sample size and the consequent selective presentation of results due to multiple comparisons.
Increased public awareness of the disease along with more willingness to report symptoms to the family doctor may be a significant factor, with consequent earlier presentation of cases.
The very first clinical presentation of XLI may occur at birth because efficient desulfation of DHEAS and consequent conversion of DHEA to estrogens is important for cervical softening (211), which would be disrupted in STS deficiency.
Frequently, one of the ends of the tube is patent, leading to decompression of the tubal obstruction with discharge and consequent shrinkage of the pelvic mass, resulting in a temporary resolution of symptoms, as described in the clinical presentation.
During the predominantly anti-inflammatory stages, monocytes are deactivated, resulting in decreased HLA-DRB3 and consequent reduced antigen presentation, which is proposed as a major feature of sepsis-induced immunodepression[ 55].
Once cleavage occurs, aggregation of the fragments and consequent formation of NIs follows.
With soaring economic growth has come soaring consumption, and consequent piles of trash.
This is due to pre-1994 government policies and consequent isolation of the country.
Despite all the antics and consequent lack of sleep, I found him charming and very entertaining.
Intestinal exposure to gliadin leads to zonulin upregulation and consequent disassembly of intercellular tight junctions and increased intestinal permeability.
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