Sentence examples for and consequent downregulation of from inspiring English sources
Re-expression of miR-124 by 5-AzadC treatment was associated with emergence of a partial euchromatin histone code and consequent downregulation of CDK6.
A loss of copy number of Daple DNA, and consequent downregulation of gene expression and function was noted in the primary tumors, predominantly among the tumors with CIN.
We have previously shown that BMPs mediated growth arrest and apoptosis in myeloma cells by activation of SMAD1/5/8 and consequent downregulation of MYC [ 12].
First, donepezil is a non-competitive inhibitor of AChE, which may result in the development of tolerance to donepezil and consequent downregulation of ACh receptors.
Collectively, these findings suggest that Nanog, miR-17/20a, and Trp53inp1 are involved in the control of NSC proliferation and S-phase entry through Nanog-induced upregulation of miR-17/20a miR-17/20auent downregulandon of p53 pathway consequentTrp53inp1.
K5cre-CMVcaNrf2 mice had a milder epidermal phenotype at 6 m compared with P32 due to partial silencing of caNrf2 expression and consequent downregulation of Nrf2 target genes (Schäfer et al, 2012).
Specifically, the C allele induced the repression of let-7 by Lin28, resulting in an increased expression of Lin28 and the consequent downregulation of mature let-7.
Therefore, these results demonstrate that, as expected, the overexpression of 51A and the consequent downregulation of SORL1 protein isoform cause a significant overproduction of Aβ.
For this reason, a gradual reduction in insulator activity in the larval and pupal stages could result in the spreading of PcG silencing from PREs in inactive cis-regulatory domains to their flanking active neighbors and the consequent downregulation of Abd-B gene activity in posterior parasegments.
It also begs the fundamental question of whether or not hGnRHR undergo agonist-induced internalization and consequent downregulation.
Patients with Diamond-Blackfan anaemia (DBA) show haploinsufficiency of the closely related ribosomal protein RPS19, and show a consequent downregulation of multiple ribosomal- and translation-related genes.
