The phrase "and consequences of alterations" is correct and usable in written English.
It can be used when discussing the effects or outcomes that result from changes or modifications in a particular context.
Example: "The study examined the effects of climate change and consequences of alterations in weather patterns on agriculture."
Alternatives: "and effects of changes" or "and outcomes of modifications".
However, in chronic diseases and in AMLs with normal karyotype, the extent, causes, identities, exact roles and consequences of epigenetic alterations have long remained elusive.
It is anticipated that on-going studies will provide data that more rigorously test this hypothesis and provide insights into gestational age-dependent programming effects and the consequences of alterations in intrauterine life on risk profiles for adult diseases.
However, the disruption of miRNA expression observed in human cancers needs to be understood by analysing the causes and consequences of the miRNA alterations.
While some case studies may show clear signatures of changing nutrition on the evolution of nutrient use and life-history traits, it is important to note that nutrient use is a composite trait driven by, and interacting with, a multitude of loci and metabolic pathways, highlighting the potential for complex and rapid evolutionary consequences of alterations to nutrient supply.
The pathophysiological mechanisms behind and the clinical consequences of alterations in expression of these gene classes in acute rejection, injury and dysfunction vs. protection and immunoregulation, prompt further analyses and open new aspects for therapeutic approaches.
The increases in glucose uptake and glycolytic pathway activation are consequences of alterations in a range of metabolic enzymes and proteins.
Further functional work is required to investigate the causes and consequences of these mRNA expression alterations with age.
Of note, no major change in metabolic gene pathways was observed in response to TBL1 inhibition (Supplementary Table S1), implying that the metabolic alterations described above (Fig 2C and D) may also represent secondary consequences of alterations in proliferation and/or cell growth.
[72], [93], [94], [95], [96], [97], widespread differences in Mn2+ accumulation at 26 hr between DAT KO and WT mice are likely to represent of indirect consequences of alterations in dopaminergic signaling induced directly by deletion of DAT.
To test the physiological consequences of alterations in hippocampal neurogenesis, wt and p50−/− mice were also evaluated at the behavioural level.
