Sentence examples for and consecutive activation of from inspiring English sources

In a candidate screen, we identified macrophage-derived TGF-β and consecutive activation of the β-catenin pathway as mechanisms of action.

All together, the data suggest a model in which M2 polarized macrophages regulate EMT through TGF-β signaling and consecutive activation of the β-catenin pathway.

Collectively, the data suggest a model in which TAMs induce EMT in intratumoral epithelial cells through paracrine TGF-β signaling and consecutive activation of the β-catenin pathway.

In continuation, when the effects of hyaluronan on fibrosarcoma cell adhesion and the respective mechanism of its action were examined, it was demonstrated that HA regulates fibrosarcoma cell adhesion through interaction with its RHAMM receptor and consecutive activation of FAK and ERK1/2 signaling pathways [ 121].

In the last years several studies could prove that adiponectin causes NO production in endothelial cell cultures by binding to its receptors and a consecutive activation of APPL1, AMPK and endothelial nitric oxidase (eNOS) [ 22- 25].

Therefore, the mechanism, by which CpG-ODN is able to protect the heart, seems to be the induction of IL-10 expression and a consecutive activation of the PI3K/Akt pathway.

We propose that the link between acidic pH and iron starvation response may be caused be the H2O2 dependent conversion of ferrous into ferric iron, resulting in the inactivation of DtxR and the consecutive activation of RipA, the two regulators of iron homeostasis in C. glutamicum (Fig. 6).

Nor did this study address the consecutive activation of TAK1/mitogen-activated protein kinase kinase (MEK /protein kinase B (AKT /NFκB and SMAD pathways upon TGF-β stimulation as Gingery et al. [ 55] did in osteoclasts.

TP can be mimicked by consecutive activation of PKA and PKC prior to the ischaemic episode, and this intervention, which is both clinically feasible and more cardioprotective than IP, does decrease the pre-ischaemic glycogen content of the heart suggesting that it probably maintains HK2 binding to mitochondria (Khaliulin et al., 2010; 2014).

Both signaling pathways are activated by numerous growth factor receptors and mediate intracellular signals by the consecutive activation of downstream proteins.

Thus, Scenario 3 is characterized by a consecutive activation of functional modes remaining active during a period substantially larger than the time scale of the relevant functional process (here the finger movement).