Sentence examples for and concomitant activation of from inspiring English sources

Mutant cerebella have severely reduced proliferation and increased differentiation of CGNPs due to a significant decrease in Shh activity and concomitant activation of Wnt signaling in SmoCKO CGNPs, suggesting that this pathway is involved in cross-talk with the Shh pathway in regulating CGNP proliferation.

Increased NAD+ levels and concomitant activation of SIRT1 might lead to reduction in several amino acids, which activates the AAR pathway in CD38-null mice.

Upon starvation or lysosomal stress, inhibition of mTOR and concomitant activation of the phosphatase calcineurin by TRPML1-mediated lysosomal calcium release induces TFEB dephosphorylation.

The uptake of oxLDL and concomitant activation of the O2-producing NAD(P H oxidase and/or oxLDL as a self-contained emitter of O2 are believed to trigger these malfunctions.

This is notably supported by the demonstration by Becq et al that TNAP inhibition enhances the phosphorylation and concomitant activation of the Cystic Fibrosis Trans-membrane receptor (CFTR) [52].

Finally, in a number of studies in monkeys, overlapping and concomitant activation of different areas in the parietal lobe and premotor cortex during planning of reaching movements have been clearly demonstrated [11], [13], [14].

The loss of PTEN (phosphatase and tensin homolog) in PC-3, PC-3M and ALVA31 cells may have also contributed to this EMT [39], [40] and the concomitant activation of AKT and PI3 Kinase pathways.

The peptide induced a rapid alkalinization of the culture medium of tobacco suspension-cultured cells and a concomitant activation of an intracellular mitogen-activated protein kinase [ 9].

Furthermore, hyperglycemia induces specific and long-lasting epigenetic modifications [ 14, 15, 28, 29, 52, 57, 58]; glucose-induced persistent transcriptional activation of p65 in vascular cells is associated with methylation of H3K4 and hypomethylation of H3K9, and the concomitant activation of NF- kB is subsequently associated with increased inflammatory response [ 14].

This result is not unexpected, however, because activation of NOX2 requires not only the signaling pathway described here, but also p47phox phosphorylation at additional sites and the concomitant activation of both rac1 and phospholipase A2.

Unless the experimental conditions are optimized oxidative stress-inducing agents are likely to influence many physiological parameters and a concomitant activation of these separate signal transduction and regulatory networks can be predicted to reach an appropriate stress response at the level of transcriptome.