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The primary efficacy measure for this ABPM sub-study was the change from baseline in 24-hour ambulatory dBP after 6 months between rosiglitazone and comparator in the two background therapy groups.
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In addition, since this study focused on immigrants and comparators in the general population to help provide a meaningful comparison.
There was no significant difference in change in HbA1c level between ILPS and comparators, in the proportion of patients achieving the HbA1c goals of ≤6.5 or <7%, in weight change, or in daily insulin doses.
There was no statistically significant difference in weight change between ILPS and comparators in the full analysis (0.223 kg [95% CI −0.81 to 1.26]), in analysis of studies using once-daily insulin dosing (−0.34 kg [−1.21 to 0.56]), or in the analysis excluding the abstract (0.431 kg [−0.81 to 1.67]) (Table 1).
It identified specific areas where the population, intervention and comparator used in the studies differed to those described in the scope.
Comparing these findings with the difference in scores among participant and comparator households in the LIG program (HDDS: 0.9 points, FCS: 4.4 points) suggests that achievements in this program were comparable with other food assistance programs, but that LIGs may have more potential to increase dietary diversity than food consumption relative to other intervention options.
While directionally slightly higher for both imipenem and comparator arms in the trials employing blinding, these general rates persisted across all sensitivity analyses.
Table 1 provides a summary of the interventions and comparators used in the studies.
Related to this, the interventions and comparators used in the models differ.
There was no statistically significant difference in daily insulin dose between ILPS and comparators either in the full analysis (−0.04 units/kg [95% CI −0.09 to 0.01]) or in the analysis excluding the abstract (−0.03 units/kg [−0.09 to 0.04]) (Table 1).
Bevacizumab is more effective and less costly than the comparator in the contrast sensitivity model and the visual acuity model.
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