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The second model system examined chronic effects by knocking out the cavin-3 locus in the mouse and characterizing the consequences of loss of cavin-3 in embryonic fibroblasts.
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We performed mutation profiling of formalin-fixed paraffin embedded tumors of multi-regional colon cancer and characterized the consequences of intra- and inter-tumor heterogeneity and metastasis using targeted re-sequencing.
Current and future studies are aimed at characterizing the consequences of relocalization of L22 during viral infection and tumorigenesis in an effort to understand the role of L22 during these as well as normal cellular processes.
Further research into MeHg-(PhSe 2 interactions will be helpful in characterizing the consequences concomitant exposures to these and related compounds.
In characterizing the consequences of ALK-5 inhibition, it will be of interest to determine whether astrogliogenesis is indeed inhibited by employing markers of immature astrocytes such as vimentin or Zebrin II.
This proinflammatory transcriptional response provides a useful readout for characterizing the consequences of mutation or knockdown of host genes involved in the immune response.
In the present study, we extended this observation by further characterizing the consequences of treatment with AHR antagonists or molecular inhibitors on cardiomyocyte development.
The concept involves understanding gene function by identifying patients harboring specific mutations and characterizing the physiologic and clinical consequences of these mutations.
We describe the activity of a highly selective, potent, reversible, and orally available small molecule FASN inhibitor that has not been described previously and characterize the biological consequences of FASN inhibition using in vitro and in vivo preclinical tumor models.
To further investigate the functional significance of SMAR1 in DSB repair and characterize the cytological consequences of SMAR1 deficiency in response to DNA damage, we examined the chromosome spreads that were prepared from SMAR1 overexpressed and knockdown HCT116 cells.
In this study we finely map the genome-wide targets of the CREB protein across all known and predicted human promoters, and characterize the functional consequences of a subset of these binding events using high-throughput reporter assays.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com