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But the problem with those statistics is that they are based on what the patients themselves report after they return home and cannot be monitored directly.
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Such experiments cannot be controlled, all threats cannot be monitored and all levels of toxicity cannot be investigated.
Perhaps the treatment duration or concentrations (or both) were sub-therapeutic for patients with elevated creatinine clearance, clearly documenting the risk associated with a so-called PK-PD-optimized antibiotic strategy when blood concentrations cannot be monitored and adjusted to stay above the MIC of the responsible pathogens [ 90].
Despite longer doripenem infusions to optimize targeted antibiotic concentrations above the pathogens' MICs during the 8-hour interval, this protocol performed more poorly, clearly documenting the risk associated with a so-called PK-PD-optimized antibiotic strategy when blood concentrations cannot be monitored and adjusted to stay above the responsible pathogens' MICs.
There is no radiographic follow-up and consequently the development of osteoarthritis cannot be monitored.
In many cases the structural changes cannot be monitored directly and surrogate markers of improvements must be used.
In fact, the crack position cannot be monitored during ECT tests and the crack length cannot be varied by repositioning a single specimen.
Third, the serum repository was harvested during a single cross-sectional survey in the early nineties and time trends in HSV seroprevalence in Switzerland cannot be monitored using these data.
However, "Pitching" of the shoulder, i.e. rotation about the long axis of the clavicle cannot be monitored by this model approach (and neither by universal goniometry), which does not take any information of the scapula into account.
In particular, when jointly analyzing gene expression and interaction data one should consider that: Many cellular processes cannot be monitored by studying gene expression alone.
Furthermore, our analysis does not have the power to detect abnormal outcomes that occur at relatively low background rates or rare abnormalities, and the issues of long-term social or functional development cannot be monitored.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com