Exact(1)
The selective ER inhibitor, fulvestrant, inhibits estrogen signaling through the ER in two ways: by competing with estradiol binding to the ER, and by increasing the turnover of ER to decrease the ER protein level in breast cancer cells.
Similar(59)
Our data indicate that activation of IKKβ by DNA damage may injure neurons by increasing the turnover of WT Htt.
GH administration may increase the turnover of LDL to a higher degree than indicated by changes seen in serum LDL-C concentrations (31), and GH increases very LDL-apolipoprotein B turnover (32).
This increases the turnover of high-energy phosphate compounds.
Blockholders further extend this framework by significantly influencing management replacements' effectiveness by increasing the likelihood of CEO turnover.
By increasing the rate of cellular turnover, these products exfoliate the skin, soften fine lines and improve skin texture and tone.
In addition, our study expands on previous studies by demonstrating that species invasion can alter compositional stability by increasing the rate of species turnover.
This finding suggested that, at least in our system, cells responded to an increase in AV abundance by increasing the rate of lysosomal turnover.
Oxidized proteins in cells are rapidly degraded by the 20S proteasome and increased 20S proteasome activity would likely increase the turnover rate of these damaged proteins [ 9].
As shown in Figure 5F, Fam20A increases the turnover number (kcat) of Fam20C by almost 20 fold.
Alternatively, they could increase the rate of cell division and turnover, increasing the risk of cancer.
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