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It may contribute to BC pathogenesis by augmenting cell proliferation via stimulation of cell cycle progression and by increasing the expression of genes involved in angiogenesis and metastasis.
Collectively, these results demonstrate that ER stress induces beta cell sensitivity to IL-1 β by degrading the anti-apoptotic Bcl-2 protein A1 and by increasing the expression of the highly pro-apoptotic BimS isoform.
The elimination of Drosophila GCs was found to modulate IIS, by increasing nuclear localization of the Drosophila homolog of DAF-16 (called dFoxo), and by increasing the expression of Drosophila insulin- like peptides (dilps) [ 16].
Although more research is needed, activation of the (pro renin receptor may contribute to the pathology of renal disease by increasing local Ang II formation and by increasing the expression of profibrotic mediators.
Mechanistically, oxaliplatin promotes over-excitability by drastically lowering the expression of distinct potassium channels (TREK1, TRAAK) and by increasing the expression of pro-excitatory channels such as the hyperpolarization-activated channels (HCNs).
One of the mechanisms by which CD28 signaling protects against apoptosis is by preventing CD95 ligand (FasL) up-regulation and by increasing the expression of the anti-apoptotic proteins c-FLIP short and Bcl-xL (Kirchoff et al 2000).
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By increasing the expression of VvCBF4 the tolerance of plant to cold stress increased.
This is partly done by increasing the expression of CTGF.
By increasing the expression levels of three genes involved in processing light, they improved tobacco yields by 20percentt.
We found that increasing the expression of c-kit is accompanied by an increase of zonulin expression.
Corticosterone treatment increased the expression of POMC by 87% and AGRP by 45% in ADX rats.
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