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WDR5-0102-bound WDR5 has a backbone RMSD (root mean square deviation) of 0.4 Å (1 Å=0.1 nm) relative to the structure of WDR5 in complex with MLL and RbBP5 peptides [ 37] and binds in the central cavity within the arginine-binding pocket.
A class-1 RF recognizes its cognate mRNA stop codon in the ribosome and binds in the A site.
The inhibitor is a derivative of geldanamycin, a natural product that selectively targets Hsp90 and binds in the N-terminal ATPase domain.
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Therefore, the sulfur atom of activated ISO is also able to form a di-sulfide bond with Cys61 like TAC and bind in the flavonoid-binding pocket.
In this proof-of-concept study, we screened 1280 compounds, identifying aryl bromides 1 and 2, which exhibit IC50 values of 130 μM and 65 μM and bind in the fatty acid binding pocket.
JonBenet Ramsey was found strangled and bound in the basement of her upscale home in Boulder, Colo., on Dec. 26 , 1996
Wednesday, we were thrown blindfolded and bound in the back of a pickup truck and driven along the Mediterranean coast toward Colonel Qaddafi's hometown, Surt, a six-hour drive.
Voltammetric and amperometric measurements allowed to detect FcBA forms – free and bound in the boronate complex.
From this, we can determine the polynomial solvability of abduction problems and, in addition, present a new heuristic for branch and bound in the non-polynomial cases.
In this section, we present an example for which the branch and bound in the LINGO software and the genetic algorithm are utilized as solution methods.
Our studies confirm that the HDACi induce the formation of and bind in the HDAC8-specific subpocket, offering insights into isoform-specific inhibition.
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