Here, we demonstrate that the longer repeat lengths generate RNA foci that are toxic to neurons and bind the RNA binding proteins SF2, SC35, and hnRNP-H.
The regulation of gene expression in a cell relies to a major extent on transcription factors, proteins which recognize and bind the DNA at specific binding sites (response elements) within promoter regions associated with each gene.
Therefore, this down-cis conformation of NikR corresponds to a specific binding conformation that can recognize and bind the nik operon with the measured "high affinity" or nanomolar dissociation constant (2, 4).
CCK and gastrin share an amidated carboxy-terminal pentapeptide sequence (46) and bind the same CCK-A and CCK-B receptors, with gastrin preferentially binding CCK-B (47 – 47).
The first factor to locate and bind the promoter is TFIID, one of whose subunits is the TATA-box binding protein (TBP).
For men young and handsome enough there are form-fitting lace and net tops along with patterned or bejeweled pants that grasp and bind the lower body.
With pity and tenderness, one believes her, and her sliver of hapless self-knowledge after the irrevocable fact cuts deeper, perhaps, than the more spectacular crimes that both sever and bind the haunted characters who populate this dreamy prison.
However, UK Sport chiefs and politicians, who have already guaranteed funding at a similar level for the Tokyo cycle, are adamant that British medal success in Rio can help heal those wounds and bind the nation back together.
One residue, Lys 125, is pivotal for antithrombin to recognize and bind the nonreducing-end trisaccharide of the pentasaccharide in an initial low-affinity complex.
Aside from the facts that pericentromeres and mat contain nearly identical sequences and bind the same set of proteins4,5, a dcr1− swi6− double mutant fails to initiate and maintain mat silencing8.
Graduating PhD student Judith Kribelbauer aims to understand at a mechanistic level how transcription factors recognize and bind the DNA of a target gene and by doing so, regulate that particular gene's transcription.
