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Therefore, the sulfur atom of activated ISO is also able to form a di-sulfide bond with Cys61 like TAC and bind in the flavonoid-binding pocket.
In this proof-of-concept study, we screened 1280 compounds, identifying aryl bromides 1 and 2, which exhibit IC50 values of 130 μM and 65 μM and bind in the fatty acid binding pocket.
Our studies confirm that the HDACi induce the formation of and bind in the HDAC8-specific subpocket, offering insights into isoform-specific inhibition.
This would allow zinc clusters to reach their cognate DNA sites and bind in the major groove in the same way as Gal4.
The observation window covers only 36% of the area of the tube cap, and only those cubes which fall and bind in the proper orientation (i.e., with transparent sides facing the camera) will be detected.
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JonBenet Ramsey was found strangled and bound in the basement of her upscale home in Boulder, Colo., on Dec. 26 , 1996
Wednesday, we were thrown blindfolded and bound in the back of a pickup truck and driven along the Mediterranean coast toward Colonel Qaddafi's hometown, Surt, a six-hour drive.
Voltammetric and amperometric measurements allowed to detect FcBA forms – free and bound in the boronate complex.
From this, we can determine the polynomial solvability of abduction problems and, in addition, present a new heuristic for branch and bound in the non-polynomial cases.
In this section, we present an example for which the branch and bound in the LINGO software and the genetic algorithm are utilized as solution methods.
The urban area has a total area of 145.8sqkm (Ezenwaji, 2009) and bound in the northeast by Isi Uzo LGA, northwest by Igbo-Etiti LGA, in the northwest by Udi LGA, and south by Nkanu West and Nkanu East LGAs.
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CEO of Professional Science Editing for Scientists @ prosciediting.com