Using the rule of 10 events or observations required per coefficient estimated in a model and adjusting for the design factor (using intracluster correlation coefficient of 0.02 for prescribing and average cluster size of 8000), our study required a total of 14 000 events or observations to estimate the models' coefficients with adequate precision.
As an example, if we want to compute the clustering coefficient over an ensemble, we compute: where Ncomb is the number of elements of and Ci is the average clustering of the network obtained merging together the layers corresponding to.
Fig. 4 Average clustering of the maritime network (1890 2000) Fig. 5 Average shortest path lenght (1890 2000).
This SNP had AFD of 0.05 between the elite and average clusters, noting that more than half of the 45,878 SNP loci had AFD greater than 0.10 between the two clusters.
You and your little rodent friends start out living an average life in an average cluster of cages, and every day, for ten days, a nice man in a white lab coats gives you 10 grams of finely ground Purina lab crackers precisely at noon (you don't know it's noon, but you eventually pick up on the general time).
Using the WOMBAT and PubChem MLSMR datasets we investigated the relation between varying the similarity threshold applied on the similarity matrix and the average clustering coefficient of the emerging similarity-based networks.
To detect an effect size of 0.35 SD between the intervention and comparison groups, with 80% power and assuming an ICC of 0.04 and an average cluster size of 12, we require 186 patients in each arm from a minimum of 31 clusters (rehabilitation units).
Recently, it has been shown that disease genes avoid 'dense clustering neighborhoods' and have an average clustering coefficient of 0.015 [ 9].
A recent study of network properties of disease genes has demonstrated that the disease genes avoid dense clustering neighborhood compared to essential genes and have an average clustering coefficient of 0.015 [ 9].
With ten schools and an average cluster size of 60 (×2 classes of 30 pupils), the design effect is: 1 + 60 – 1 0.01 = 1.59 Accordingly the adjusted sample size is 484 × 1.59 = 770.
