Exact(2)
Lawrence Hunter has once again taken a complicated field and reduced it to a set of key principles and associated examples.
aIn order to provide assured version control of the schema and associated examples, it is currently hosted on a local code trunk of the LabTrove software, but accessibility is advertised via the Dial-a-Molecule website.
Similar(58)
We tested the one-sided hypotheses that parameter estimates are larger than 0 with likelihood ratio tests, by comparing models where a given parameter was set to 0 with a model where all parameters were allowed to assume non-negative values [see [ 59] for details of this model and associated example script].
In contrast, if model fitting were to be done using the original oscillating waveform and associated methods (for example by minimizing the deviation between experimental and model signals), invalidation of the single-gene model may not be as clear because the imperfect overlap between the fitted model and data may be blamed on noise.
Affected individuals presented with poor dental aesthetics and associated pain, for example on eating or drinking.
For this reason, to provide effective traction, the jaws of laparoscopic graspers feature ridges or toothed profiles to minimize slip and for this reason, the bowel is often grasped too tightly, increasing risk of trauma and associated complications, for example, delayed healing, adhesion formation, and even perforation [ 1].
The revised Figure 3 figure supplement 1A and associated text now show examples of metastatic nodules that have either high or low RBM47 expression as determined by immunohistochemistry against RBM47 and human vimentin.
These results also could indicate cIAP2 as a possible therapeutic target to modulate microglia pro-inflammatory activation and associated neurotoxicity observed, for example, in neurodegenerative disorders.
However, they are challenged in this role due to poor personal health and associated risk factors, for example, being overweight [ 4, 6- 9, 34] and not meeting public health physical activity recommendations [ 6, 9].
We describe an increased rate of mutations in receptor tyrosine kinases (RTKs) and associated signaling effectors, for example, in EGFR, ERBB3, KRAS and MAP2K2, pointing to a role of aberrant RTK signaling in the development or progression of MM.
Figure 1 shows comparative immunohistochemical investigations with hematoxylin & eosin (HE), glial fibrillary acidic protein (GFAP) and MIB-1 in the cases of grade II PXA and associated anaplastic PXA, and illustrative examples of histological assessment of BRAF V600E mutation (PXA-3) and CD34 immunoreactivity (PXA-1) are included on Additional file 2: Figure S1.
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