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We ascertained a range of characteristics, including psychological comorbidities, hepatic comorbidities and risk factors, medications, and health care services, that were specified a priori and ascertained based on the presence of diagnoses, procedures, and pharmacy dispensings in the health care claims during the 12-month baseline.
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On the other hand, regular use (≥2 or ≥3 times per week) of aspirin and other NSAIDs was ascertained based on the baseline questionnaires, and the duration of use was estimated based on the responses to the same questions in each follow-up questionnaire in the aforementioned prospective cohort studies [ 11, 43].
Epilepsy history (new-onset vs. chronic care), type of seizure (if documented), and medication information was ascertained based on longitudinal review of medical records and intake history for patients new to the medical center.
Nano-indentation was used to determine the Young's modulus and hardness of the coatings, while microtensile tests were used to introduce controlled strains in the coatings through the cp Ti and TiAl6V4 alloy substrates, from which the strength, fracture toughness and adhesion behaviour could be ascertained based on multiple cracking and delamination events.
Indications for shoulder and wrist arthroscopy were ascertained based on primary ICD-9-CM diagnoses codes.
Birth weight was measured immediately after birth by midwives, and gestational age was ascertained based on the date of the last menstrual period (48).
Receipt of chemotherapy was ascertained based on the presence of one or more claims for a chemotherapy drug or administration, which were identified using HCPCS and ICD-9-CM codes in the healthcare claims database.
Cases were likely unaware of RAs and therefore unlikely to be differentially ascertained based on this basis.
Hypertensive status was ascertained based on self-report and the mean BP value of three measurements.
Other risk factors like alcohol intake, body mass index (BMI) and hormone replacement therapy (HRT) were also ascertained based on their medical history recorded in the GPRD.
For example, only one hybrid (field identification number 1065) from site JR could be ascertained based on morphological criteria during field sampling and our genetic analysis recognized it to be an F2.
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